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Article

Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells.

Stem cell reports - 8 Dec 2015

Ring Karen L, An Mahru C, Zhang Ningzhe, O'Brien Robert N, Ramos Eliana Marisa, Gao Fuying, Atwood Robert, Bailus Barbara J, Melov Simon, Mooney Sean D, Coppola Giovanni, Ellerby Lisa M

Abstract excerpt

We utilized induced pluripotent stem cells (iPSCs) derived from Huntington's disease (HD) patients as a human model of HD and determined that the disease phenotypes only manifest in the differentiated neural stem cell (NSC) stage, not in iPSCs. To understand the molecular basis for the CAG repeat expansion-dependent disease phenotypes in NSCs, we performed transcriptomic analysis of HD iPSCs and HD NSCs compared...

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Identifiers

PMID: 26651603
DOI: 10.1016/j.stemcr.2015.11.005
PMCID: PMC4682390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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