Article
Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease.
Neurobiology of disease - 1 Dec 2016
Arteaga-Bracho Eduardo E, Gulinello Maria, Winchester Michael L, Pichamoorthy Nandini, Petronglo Jenna R, Zambrano Alicia D, Inocencio Julio, De Jesus Chirstopher D, Louie Joseph O, Gokhan Solen, Mehler Mark F, Molero Aldrin E
Abstract excerpt
The mutation in huntingtin (mHtt) leads to a spectrum of impairments in the developing forebrain of Huntington's disease (HD) mouse models. Whether these developmental alterations are due to loss- or gain-of-function mechanisms and contribute to HD pathogenesis is unknown. We examined the role of selective loss of huntingtin (Htt) function during development on postnatal vulnerability to cell death. We employed...
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