Article
Multilocus genetic risk scores for coronary heart disease prediction.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2013
Ganna Andrea, Magnusson Patrik K E, Pedersen Nancy L, de Faire Ulf, Reilly Marie, Arnlöv Johan, Sundström Johan, Hamsten Anders, Ingelsson Erik
Abstract excerpt
OBJECTIVE: Current guidelines do not support the use of genetic profiles in risk assessment of coronary heart disease (CHD). However, new single nucleotide polymorphisms associated with CHD and intermediate cardiovascular traits have recently been discovered. We aimed to compare several multilocus genetic risk score (MGRS) in terms of association with CHD and to evaluate clinical use. APPROACH AND RESULTS: We...
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