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Article

A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses.

Lancet (London, England) - 23 Oct 2010

Ripatti Samuli, Tikkanen Emmi, Orho-Melander Marju, Havulinna Aki S, Silander Kaisa, Sharma Amitabh, Guiducci Candace, Perola Markus, Jula Antti, Sinisalo Juha, Lokki Marja-Liisa, Nieminen Markku S, Melander Olle, Salomaa Veikko, Peltonen Leena, Kathiresan Sekar

Abstract excerpt

BACKGROUND: Comparison of patients with coronary heart disease and controls in genome-wide association studies has revealed several single nucleotide polymorphisms (SNPs) associated with coronary heart disease. We aimed to establish the external validity of these findings and to obtain more precise risk estimates using a prospective cohort design. METHODS: We tested 13 recently discovered SNPs for association...

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Identifiers

PMID: 20971364
DOI: 10.1016/S0140-6736(10)61267-6
PMCID: PMC2965351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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