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How close are we to implementing a genetic risk score for coronary heart disease?

Expert review of molecular diagnostics - 1 Oct 2017

Beaney Katherine, Drenos Fotios, Humphries Steve E

Abstract excerpt

INTRODUCTION: Genome-wide association meta-analysis have now identified more than 150 loci where common variants (SNPs) are significantly associated with coronary heart disease (CHD) and CHD end points. Areas covered: The authors review publications from their own laboratory and published recently where identified CHD risk SNPs are used in combination, and 'scaled' by their effect size, to create a 'weighted'...

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PMID: 28816567
DOI: 10.1080/14737159.2017.1368388

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