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Article

A genetic risk score is associated with incident cardiovascular disease and coronary artery calcium: the Framingham Heart Study.

Circulation. Cardiovascular genetics - 1 Feb 2012

Thanassoulis George, Peloso Gina M, Pencina Michael J, Hoffmann Udo, Fox Caroline S, Cupples L Adrienne, Levy Daniel, D'Agostino Ralph B, Hwang Shih-Jen, O'Donnell Christopher J

Abstract excerpt

BACKGROUND: Limited data exist regarding the use of a genetic risk score (GRS) for predicting risk of incident cardiovascular disease (CVD) in US-based samples. METHODS AND RESULTS: By using findings from recent genome-wide association studies, we constructed GRSs composed of 13 genetic variants associated with myocardial infarction or other manifestations of coronary heart disease (CHD) and 102 genetic variants...

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Identifiers

PMID: 22235037
DOI: 10.1161/CIRCGENETICS.111.961342
PMCID: PMC3292865

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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