Article
Genetic risk prediction and a 2-stage risk screening strategy for coronary heart disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2013
Tikkanen Emmi, Havulinna Aki S, Palotie Aarno, Salomaa Veikko, Ripatti Samuli
Abstract excerpt
OBJECTIVE: Genome-wide association studies have identified several genetic variants associated with coronary heart disease (CHD). The aim of this study was to evaluate the genetic risk discrimination and reclassification and apply the results for a 2-stage population risk screening strategy for CHD. APPROACH AND RESULTS: We genotyped 28 genetic variants in 24 124 participants in 4 Finnish population-based,...
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