Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Flumequine enhances the in vivo mutagenicity of MeIQx in the mouse liver.

Archives of toxicology - 1 Aug 2013

Kuroda K, Kijima A, Ishii Y, Takasu S, Jin M, Matsushita K, Kodama Y, Umemura T

Abstract excerpt

The combined effects of various carcinogens found in food products are a concern for human health. In the present study, the effects of flumequine (FL) on the in vivo mutagenicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in the liver were investigated. Additionally, we attempted to clarify the underlying mechanisms through comprehensive gene analysis using a cDNA microarray. Male gpt delta mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin D1
Share to Cytochrome P-450 CYP1A2
Share to Drug Synergism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluoroquinolones

Share to Glucuronosyltransferase

Share to Hepatocytes

Share to Phenobarbital

Share to Quinoxalines

Source

Identifiers

PMID: 23681119
DOI: 10.1007/s00204-013-1064-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Flumequine enhances the in vivo mutagenicity of MeIQx in the mouse liver.PMID 23681119Read ↗

Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).Semantic proximity Read ↗

In vivo genotoxicity of 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline in lacI transgenic (Big Blue) mice.Semantic proximity Read ↗

Lack of in vivo mutagenicity and oxidative DNA damage by flumequine in the livers of gpt delta mice.Semantic proximity Read ↗

Low dose genotoxicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in gpt delta transgenic mice.Semantic proximity Read ↗

In vivo mutational analysis of liver DNA in gpt delta transgenic rats treated with the hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3-methylimidazo[4,5-f]quinoline, and di(2-ethylhexyl)phthalate.Semantic proximity Read ↗

Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans.Semantic proximity Read ↗

Beta-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice.Semantic proximity Read ↗

Hepatocarcinogen quinoline induces G:C to C:G transversions in the cII gene in the liver of lambda/lacZ transgenic mice (MutaMouse).Semantic proximity Read ↗

In vivo mutagenicity of conazole fungicides correlates with tumorigenicity.Semantic proximity Read ↗

Hydroxychloroquine induces oxidative DNA damage and mutation in mammalian cells.Semantic proximity Read ↗

Organ variation in the mutagenicity of MeIQ in Big Blue lacI transgenic mice.Semantic proximity Read ↗

Hepatocarcinogen 4-methylquinoline induced G:C to C:G transversions in the cII gene in the liver of lambda/lacZ transgenic mice (Muta™Mouse).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.