Article
Hepatocarcinogen quinoline induces G:C to C:G transversions in the cII gene in the liver of lambda/lacZ transgenic mice (MutaMouse).
Mutation research - 30 Nov 2000
Suzuki T, Wang X, Miyata Y, Saeki K, Kohara A, Kawazoe Y, Hayashi M, Sofuni T
Abstract excerpt
Quinoline is carcinogenic to the liver in rodents, but it is not clear whether it acts by a genotoxic mechanism. We previously demonstrated that quinoline does induce gene mutation in the liver of lambda/lacZ transgenic mice. In the present report, we reveal the molecular nature of the mutations induced by quinoline in the lambda cII gene, which is also a phenotypically selectable marker in the lambda transgene....
Topics
- Animals
- Bacteriophage lambda
- Base Sequence
- Carcinogens
- DNA Primers
- DNA, Recombinant
- Lac Operon
- Liver
- Male
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Quinolines
- Sister Chromatid Exchange