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Lack of in vivo mutagenicity and oxidative DNA damage by flumequine in the livers of gpt delta mice.

Archives of toxicology - 1 Jan 2007

Kuroiwa Yuichi, Umemura Takashi, Nishikawa Akiyoshi, Kanki Keita, Ishii Yuji, Kodama Yukio, Masumura Ken-ichi, Nohmi Takehiko, Hirose Masao

Abstract excerpt

Flumequine (FLU), an anti-bacterial quinolone agent, has been recognized as a non-genotoxic carcinogen for the mouse liver, but recent reports have suggested that some genotoxic mechanism involving oxidative DNA damage may be responsible for its hepatocarcinogenesis. In the present study, we investigated this possibility in the mouse liver using male and female B6C3F1 gpt delta mice fed diet containing 0.4% FLU,...

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PMID: 16802149
DOI: 10.1007/s00204-006-0126-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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