Article
In vivo mutational analysis of liver DNA in gpt delta transgenic rats treated with the hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3-methylimidazo[4,5-f]quinoline, and di(2-ethylhexyl)phthalate.
Molecular carcinogenesis - 1 Jan 2005
Kanki Keita, Nishikawa Akiyoshi, Masumura Ken-Ichi, Umemura Takashi, Imazawa Takayoshi, Kitamura Yasuki, Nohmi Takehiko, Hirose Masao
Abstract excerpt
In order to cast light on carcinogen-specific molecular mechanisms underlying experimental hepatocarcinogenesis in rats, in vivo mutagenicity and mutation spectra of known genotoxic rat hepatocarcinogens N-nitrosopyrrolidine (NPYR), and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), as well as the...
Topics
- Animals
- Animals, Genetically Modified
- Carcinogens
- DNA
- DNA Mutational Analysis
- Diethylhexyl Phthalate
- Immunohistochemistry
- Liver
- Mutagens
- Mutation
- N-Nitrosopyrrolidine