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Article

Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).

The Journal of toxicological sciences - 1 Oct 2010

Okamura Toshiya, Ishii Yuji, Suzuki Yuta, Inoue Tomoki, Tasaki Masako, Kodama Yukio, Nohmi Takehiko, Mitsumori Kunitoshi, Umemura Takashi, Nishikawa Akiyoshi

Abstract excerpt

Chronic stimulus subsequent to cell injury plays an important role in cancer development, but the precise mechanisms remain unknown partly because appropriate animal models are lacking. In the present study, the effects of hepatotoxicant carbon tetrachloride (CCl(4)) on in vivo mutagenicity were investigated using gpt delta mice with or without p53. Female B6C3F(1) p53-proficient or -deficient gpt delta mice were...

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Identifiers

PMID: 20930465
DOI: 10.2131/jts.35.709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).PMID 20930465Read ↗

Flumequine enhances the in vivo mutagenicity of MeIQx in the mouse liver.Semantic proximity Read ↗

Low dose genotoxicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in gpt delta transgenic mice.Semantic proximity Read ↗

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Heterozygous p53-deficient mice are not susceptible to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) carcinogenicity.Semantic proximity Read ↗

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