Article
Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans.
Toxicology letters - 1 Oct 2014
Driessen Marja, Kienhuis Anne S, Vitins Alexa P, Pennings Jeroen L A, Pronk Tessa E, van den Brandhof Evert-Jan, Roodbergen Marianne, van de Water Bob, van der Ven Leo T M
Abstract excerpt
The zebrafish embryo (ZFE) is a promising non-rodent model in toxicology, and initial studies suggested its applicability in detecting hepatotoxic responses. Here, we hypothesize that the detailed analysis of underlying mechanisms of hepatotoxicity in ZFE contributes to the improved identification of hepatotoxic properties of new compounds and to the reduction of rodents used for screening. ZFEs were exposed to...
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