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Article

Novel mutant human immunodeficiency virus type 1 strains with high degree of resistance to cynomolgus macaque TRIMCyp generated by random mutagenesis.

The Journal of general virology - 1 Apr 2016

Sultana Tahmina, Nakayama Emi E, Tobita Satoshi, Yokoyama Masaru, Seki Yohei, Saito Akatsuki, Nomaguchi Masako, Adachi Akio, Akari Hirofumi, Sato Hironori, Shioda Tatsuo

Abstract excerpt

Old World monkey TRIM5α strongly suppresses human immunodeficiency virus type 1 (HIV-1) replication. A fusion protein comprising cynomolgus macaque (CM) TRIM5 and cyclophilin A (CM TRIMCyp) also potently suppresses HIV-1 replication. However, CM TRIMCyp fails to suppress a mutant HIV-1 that encodes a mutant capsid protein containing a SIVmac239-derived loop between α-helices 4 and 5 (L4/5). There are seven amino...

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Source

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Identifiers

PMID: 26795727
DOI: 10.1099/jgv.0.000408
PMCID: PMC4854368

Genes

TRIM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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