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Article

TRIM5α restriction affects clinical outcome and disease progression in simian immunodeficiency virus-infected rhesus macaques.

Journal of virology - 1 Feb 2015

Wu Fan, Ourmanov Ilnour, Riddick Nadeene, Matsuda Kenta, Whitted Sonya, Plishka Ronald J, Buckler-White Alicia, Starost Matthew F, Hirsch Vanessa M

Abstract excerpt

UNLABELLED: Tripartite motif-containing protein 5α (TRIM5α) is considered to be a potential target for cell-based gene modification therapy against human immunodeficiency virus type 1 (HIV-1) infection. In the present study, we used a relevant rhesus macaque model of infection with simian immunodeficiency virus from sooty mangabey (SIVsm) to evaluate the effect of TRIM5α restriction on clinical outcome. For...

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Source

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Identifiers

PMID: 25473059
DOI: 10.1128/JVI.02978-14
PMCID: PMC4338887

Genes

TRIM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TRIM5α restriction affects clinical outcome and disease progression in simian immunodeficiency virus-infected rhesus macaques.PMID 25473059Read ↗

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