Article
TRIM5α Resistance Escape Mutations in the Capsid Are Transferable between Simian Immunodeficiency Virus Strains.
Journal of virology - 15 Dec 2016
Wu Fan, Kirmaier Andrea, White Ellen, Ourmanov Ilnour, Whitted Sonya, Matsuda Kenta, Riddick Nadeene, Hall Laura R, Morgan Jennifer S, Plishka Ronald J, Buckler-White Alicia, Johnson Welkin E, Hirsch Vanessa M
Abstract excerpt
TRIM5α polymorphism limits and complicates the use of simian immunodeficiency virus (SIV) for evaluation of human immunodeficiency virus (HIV) vaccine strategies in rhesus macaques. We previously reported that the TRIM5α-sensitive SIV from sooty mangabeys (SIVsm) clone SIVsmE543-3 acquired amino acid substitutions in the capsid that overcame TRIM5α restriction when it was passaged in rhesus macaques expressing...
Topics
- Alleles
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Capsid
- Carrier Proteins
- Cercocebus atys
- Female
- Gene Expression Regulation
- Humans
- Immune Evasion
- Male
- Mutation