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Article

The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5α.

Journal of virology - 1 Mar 2018

Morger Damien, Zosel Franziska, Bühlmann Martin, Züger Sara, Mittelviefhaus Maximilian, Schuler Benjamin, Luban Jeremy, Grütter Markus G

Abstract excerpt

Rhesus TRIM5α (rhTRIM5α) potently restricts replication of human immunodeficiency virus type 1 (HIV-1). Restriction is mediated through direct binding of the C-terminal B30.2 domain of TRIM5α to the assembled HIV-1 capsid core. This host-pathogen interaction involves multiple capsid molecules within the hexagonal HIV-1 capsid lattice. However, the molecular details of this interaction and the precise site at...

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Identifiers

PMID: 29237846
DOI: 10.1128/JVI.01541-17
PMCID: PMC5809731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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