Article
Novel escape mutants suggest an extensive TRIM5α binding site spanning the entire outer surface of the murine leukemia virus capsid protein.
PLoS pathogens - 1 Mar 2011
Ohkura Sadayuki, Goldstone David C, Yap Melvyn W, Holden-Dye Kate, Taylor Ian A, Stoye Jonathan P
Abstract excerpt
After entry into target cells, retroviruses encounter the host restriction factors such as Fv1 and TRIM5α. While it is clear that these factors target retrovirus capsid proteins (CA), recognition remains poorly defined in the absence of structural information. To better understand the binding interaction between TRIM5α and CA, we selected a panel of novel N-tropic murine leukaemia virus (N-MLV) escape mutants by...
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