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Article

Regulatory phosphorylation induces extracellular conformational changes in a CLC anion channel.

Biophysical journal - 7 May 2013

Yamada Toshiki, Bhate Manasi P, Strange Kevin

Abstract excerpt

CLH-3b is a CLC-1/2/Ka/Kb channel homolog activated by meiotic cell cycle progression and cell swelling. Channel inhibition occurs by GCK-3 kinase-mediated phosphorylation of serine residues on the cytoplasmic C-terminus linker connecting CBS1 and CBS2. Two conserved aromatic amino acid residues located on the intracellular loop connecting membrane helices H and I and α1 of CBS2 are required for transducing...

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Source

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Identifiers

PMID: 23663832
DOI: 10.1016/j.bpj.2013.03.026
PMCID: PMC3647193

Genes

CLC
GCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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