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Article

CLC anion channel regulatory phosphorylation and conserved signal transduction domains.

Biophysical journal - 17 Oct 2012

Miyazaki Hiroaki, Yamada Toshiki, Parton Angela, Morrison Rebecca, Kim Sunghoon, Beth Albert H, Strange Kevin

Abstract excerpt

The signaling mechanisms that regulate CLC anion channels are poorly understood. Caenorhabditis elegans CLH-3b is a member of the CLC-1/2/Ka/Kb channel subfamily. CLH-3b is activated by meiotic cell-cycle progression and cell swelling. Inhibition is brought about by GCK-3 kinase-mediated phosphorylation of S742 and S747 located on a ∼176 amino acid disordered domain linking CBS1 and CBS2. Much of the inter-CBS...

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Identifiers

PMID: 23083714
DOI: 10.1016/j.bpj.2012.09.001
PMCID: PMC3475328

Genes

CLC
GCK
CBS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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