Article

Structural basis of ClC-3 inhibition by TMEM9 and PI(3,5)P <sub>2</sub>

2025-03-03

Abstract excerpt

The trafficking and activity of endosomes relies on the exchange of chloride ions and protons by members of the CLC family of chloride channels and transporters, whose mutations are associated with numerous diseases. Despite their critical roles, the mechanisms by which CLC transporters are regulated are poorly understood. Here, we show that two related accessory β-subunits, TMEM9 and TMEM9B, directly interact wit...

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Literature Corpus work: 4a99bf8c-46e6-5f9a-a703-45157081dc7d
DOI: 10.1101/2025.02.28.640562

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