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Article

Tryptophan Scanning Mutagenesis Identifies the Molecular Determinants of Distinct Barttin Functions.

The Journal of biological chemistry - 24 Jul 2015

Wojciechowski Daniel, Fischer Martin, Fahlke Christoph

Abstract excerpt

CLC-K chloride channels are expressed in the kidney and in the inner ear and require the accessory subunit barttin for proper function and membrane insertion. Barttin exerts multiple functions on CLC-proteins: it modifies protein stability and intracellular trafficking as well as channel activity, ion conduction, and gating. So far, the molecular determinants of these distinct barttin functions have remained...

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Identifiers

PMID: 26063802
DOI: 10.1074/jbc.M114.625376
PMCID: PMC4513129

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CLC

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Tryptophan Scanning Mutagenesis Identifies the Molecular Determinants of Distinct Barttin Functions.PMID 26063802Read ↗

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