Article

Divergent Cl <sup>−</sup> and H <sup>+</sup> pathways underlie transport coupling and gating in CLC exchangers and channels

2019-09-05

Abstract excerpt

The CLC family of anion transporting proteins is comprised of secondary active H + -coupled exchangers and of Cl − channels. Both functional subtypes play key roles in human physiology, and mutations causing their dysfunction lead to numerous genetic disorders. Current models suggest that the CLC exchangers do not utilize a classical ‘ping-pong’ mechanism of antiport, where the transporter sequentially interacts...

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Literature Corpus work: e48beaf7-fb6a-58b8-984d-80a19057338d
DOI: 10.1101/753954

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