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Article

Regulatory Conformational Coupling between CLC Anion Channel Membrane and Cytoplasmic Domains.

Biophysical journal - 1 Nov 2016

Yamada Toshiki, Strange Kevin

Abstract excerpt

CLC anion channels are homodimeric proteins. Each subunit is comprised of 18 α-helices designated "A-R" and an intracellular carboxy-terminus containing two cystathionine-β-synthase (CBS1 and CBS2) domains. Conformational coupling between membrane and intracellular domains via poorly understood mechanisms is required for CLC regulation. The activity of the C. elegans CLC channel CLH-3b is reduced by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27806270
DOI: 10.1016/j.bpj.2016.09.037
PMCID: PMC5103031

Genes

CLC
CBS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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