Article
External Zn(2+) binding to cysteine-substituted cystic fibrosis transmembrane conductance regulator constructs regulates channel gating and curcumin potentiation.
The FEBS journal - 1 Jul 2016
Wang Guangyu, Linsley Rheeann, Norimatsu Yohei
Abstract excerpt
The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is activated by ATP binding-induced dimerization of nucleotide-binding domains, the interaction between the phosphorylated regulatory (R) domain and the curcumin-sensitive interface between intracellular loop (ICL) 1 and ICL4, and the resultant inward-to-'outward' reorientation of transmembrane domains. Although transmembrane helices...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.