Article
Carboxy terminus splice variation alters ClC channel gating and extracellular cysteine reactivity.
Biophysical journal - 15 May 2006
He Liping, Denton Jerod, Nehrke Keith, Strange Kevin
Abstract excerpt
CLH-3a and CLH-3b are Caenorhabditis elegans ClC channel splice variants that exhibit striking differences in voltage, Cl(-), and H(+) sensitivity. The major primary structure differences between the channels include a 71 amino acid CLH-3a N-terminal extension and a 270 amino acid extension of the CLH-3b C-terminus. Deletion of the CLH-3a N-terminus or generation of a CLH-3a/b chimera has no effect on channel...
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