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Article

ATP-dependent chromatin remodeling and histone acetyltransferases in 5-FU cytotoxicity in Saccharomyces cerevisiae.

Genetics and molecular research : GMR - 26 Apr 2013

Matuo R, Sousa F G, Bonatto D, Mielniczki-Pereira A A, Saffi J, Soares D G, Escargueil A E, Larsen A K, Henriques J A P

Abstract excerpt

Chromatin is thought to modulate access of repair proteins to DNA lesions, and may be altered by chromatin remodelers to facilitate repair. We investigated the participation of chromatin remodelers and DNA repair in 5-fluorouracil (5-FU) cytotoxicity in Saccharomyces cerevisiae. 5-FU is an antineoplastic drug commonly used in clinical settings. Among the several strains tested, only those with deficiencies in...

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PMID: 23661467
DOI: 10.4238/2013.April.26.6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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