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Article

A role for Rad5 in ribonucleoside monophosphate (rNMP) tolerance.

Life science alliance - 1 Oct 2021

Elserafy Menattallah, El-Shiekh Iman, Fleifel Dalia, Atteya Reham, AlOkda Abdelrahman, Abdrabbou Mohamed M, Nasr Mostafa, El-Khamisy Sherif F

Abstract excerpt

Ribonucleoside monophosphate (rNMP) incorporation in genomic DNA poses a significant threat to genomic integrity. In addition to repair, DNA damage tolerance mechanisms ensure replication progression upon encountering unrepaired lesions. One player in the tolerance mechanism is Rad5, which is an E3 ubiquitin ligase and helicase. Here, we report a new role for yeast Rad5 in tolerating rNMP incorporation, in the...

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Interaction Domains and Motifs

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Source

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Identifiers

PMID: 34407997
DOI: 10.26508/lsa.202000966
PMCID: PMC8380674

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