Article
Identification of genes that affect sensitivity to 5-bromodeoxyuridine in the yeast Saccharomyces cerevisiae.
Molecular genetics and genomics : MGG - 1 May 2010
Fujii Michihiko, Miki Kensuke, Takayama Shinichi, Ayusawa Dai
Abstract excerpt
Small molecules that exhibit biological effects have been successfully used to study various biological phenomena. 5-Bromodeoxyuridine (BrdU) is a thymidine analog that affects various biological processes, such as cellular differentiation and cellular senescence in cultured mammalian cells. Although BrdU is thought to modulate these phenomena by changing chromatin structure and gene expression, the molecular...
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