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Analysis of Saccharomyces cerevisiae histone H3 mutants reveals the role of the alphaN helix in nucleosome function.

Biochemical and biophysical research communications - 26 Sept 2008

Seol Ja-Hwan, Kim Hye-Jin, Yoo Ja-Kyung, Park Hyun-Ju, Cho Eun-Jung

Abstract excerpt

To understand the role of histone H3 sub-domains in chromatin function, 35 histone H3 tandem alanine mutants were generated and tested for their viability and sensitivity to DNA damaging agents. Among 13 non-viable H3 mutants, 6 were mapped around the alphaN helix and preceding tail region. Mutants with individual alanine substitutions in this region were viable but developed multiple sensitivities to DNA...

Topics

Alanine
Alkylating Agents
Amino Acid Sequence
Amino Acid Substitution
Cell Cycle Proteins
DNA Mutational Analysis
Histones
Hydroxyurea
Methyl Methanesulfonate
Molecular Chaperones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Nuclear Proteins

Nucleosomes

Protein Structure, Secondary

Ribonucleotide Reductases

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Source

Identifiers

PMID: 18657516
DOI: 10.1016/j.bbrc.2008.07.084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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