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Analysis of Saccharomyces cerevisiae histone H3 mutants reveals the role of the alphaN helix in nucleosome function.

Biochemical and biophysical research communications - 26 Sept 2008

Seol Ja-Hwan, Kim Hye-Jin, Yoo Ja-Kyung, Park Hyun-Ju, Cho Eun-Jung

Abstract excerpt

To understand the role of histone H3 sub-domains in chromatin function, 35 histone H3 tandem alanine mutants were generated and tested for their viability and sensitivity to DNA damaging agents. Among 13 non-viable H3 mutants, 6 were mapped around the alphaN helix and preceding tail region. Mutants with individual alanine substitutions in this region were viable but developed multiple sensitivities to DNA...

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PMID: 18657516
DOI: 10.1016/j.bbrc.2008.07.084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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