Article
Comparative genome-wide screening identifies a conserved doxorubicin repair network that is diploid specific in Saccharomyces cerevisiae.
PloS one - 8 Jun 2009
Westmoreland Tammy J, Wickramasekara Sajith M, Guo Andrew Y, Selim Alice L, Winsor Tiffany S, Greenleaf Arno L, Blackwell Kimberly L, Olson John A, Marks Jeffrey R, Bennett Craig B
Abstract excerpt
The chemotherapeutic doxorubicin (DOX) induces DNA double-strand break (DSB) damage. In order to identify conserved genes that mediate DOX resistance, we screened the Saccharomyces cerevisiae diploid deletion collection and identified 376 deletion strains in which exposure to DOX was lethal or severely reduced growth fitness. This diploid screen identified 5-fold more DOX resistance genes than a comparable screen...
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