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Article

A role for Chd1 and Set2 in negatively regulating DNA replication in Saccharomyces cerevisiae.

Genetics - 1 Feb 2008

Biswas Debabrata, Takahata Shinya, Xin Hua, Dutta-Biswas Rinku, Yu Yaxin, Formosa Tim, Stillman David J

Abstract excerpt

Chromatin-modifying factors regulate both transcription and DNA replication. The yFACT chromatin-reorganizing complex is involved in both processes, and the sensitivity of some yFACT mutants to the replication inhibitor hydroxyurea (HU) is one indication of a replication role. This HU sensitivity can be suppressed by disruptions of the SET2 or CHD1 genes, encoding a histone H3(K36) methyltransferase and a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18245327
DOI: 10.1534/genetics.107.084202
PMCID: PMC2248355

Genes

CHD1
ORC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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