Article
Expression of human poly (ADP-ribose) polymerase 1 in Saccharomyces cerevisiae: Effect on survival, homologous recombination and identification of genes involved in intracellular localization.
Mutation research - 1 Apr 2015
La Ferla Marco, Mercatanti Alberto, Rocchi Giulia, Lodovichi Samuele, Cervelli Tiziana, Pignata Luca, Caligo Maria Adelaide, Galli Alvaro
Abstract excerpt
The poly (ADP-ribose) polymerase 1 (PARP-1) actively participates in a series of functions within the cell that include: mitosis, intracellular signaling, cell cycle regulation, transcription and DNA damage repair. Therefore, inhibition of PARP1 has a great potential for use in cancer therapy. As resistance to PARP inhibitors is starting to be observed in patients, thus the function of PARP-1 needs to be studied...
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