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Article

Functional studies of N-terminally modified CYP2J2 epoxygenase in model lipid bilayers.

Protein science : a publication of the Protein Society - 1 Jul 2013

McDougle Daniel R, Palaria Amrita, Magnetta Eric, Meling Daryl D, Das Aditi

Abstract excerpt

CYP2J2 epoxygenase is a membrane bound cytochrome P450 that converts omega-3 and omega-6 fatty acids into physiologically active epoxides. In this work, we present a comprehensive comparison of the effects of N-terminal modifications on the properties of CYP2J2 with respect to the activity of the protein in model lipid bilayers using Nanodiscs. We demonstrate that the complete truncation of the N-terminus changes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23661295
DOI: 10.1002/pro.2280
PMCID: PMC3719090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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