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Functional Role of Ile264 in CYP2C8: Mutations Affect Haem Incorporation and Catalytic Activity

1 Jan 2008

Abstract excerpt

The work described in this study aimed to express CYP2C8 wild-type and mutant proteins in bacterial expression system and to use the expressed proteins to investigate the structural and functional consequences of a reported allele CYP2C8(*)4 (carrying Ile264Met substitution) on protein activity. Ile264 was replaced by three different amino acids resulting in three mutant constructs, 2C8I264M, 2C8I264R and...

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PMID: 18574320
DOI: 10.2133/dmpk.23.165

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