Article
Distinct influences of carboxyl terminal segment structure on function in the two isoforms of prostaglandin H synthase.
Archives of biochemistry and biophysics - 15 Dec 2000
Guo Q, Kulmacz R J
Abstract excerpt
The cyclooxygenase activity of the two prostaglandin H synthase (PGHS) isoforms, PGHS-1 and -2, is a major control element in prostanoid biosynthesis. The two PGHS isoforms have 60% amino acid identity, with prominent differences near the C-terminus, where PGHS-2 has an additional 18-residue insert. Some mutations of the C-terminal residue in PGHS-1 and -2 have been found to disrupt catalytic activity and/or...
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