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Article

Role of the alanine at position 363 of cytochrome P450 2B2 in influencing the NADPH- and hydroperoxide-supported activities.

Archives of biochemistry and biophysics - 15 Feb 1998

Hanna I H, Teiber J F, Kokones K L, Hollenberg P F

Abstract excerpt

Escherichia coli was used to express the two closely related cytochromes P450 2B1 and 2B2 and two mutants of 2B2 in which residues Gly-303 and Ala-363 were replaced by Ser and Val, respectively. The expressed proteins were partially purified and assayed for benzphetamine and n-octylamine (NOA) binding and 7-ethoxy-4-trifluoromethylcoumarin O-deethylation (EOD), benzphetamine N-demethylation (BND) and...

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PMID: 9473308
DOI: 10.1006/abbi.1997.0534

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