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Article

Functional role of the conserved i-helix residue I346 in CYP5A1-Nanodiscs.

Biophysical chemistry - 1 Jan 2000

Meling Daryl D, Zelasko Susan, Kambalyal Amogh, Roy Jahnabi, Das Aditi

Abstract excerpt

Thromboxane synthase (CYP5A1) is a non-classical cytochrome P450 (CYP) expressed in human platelets that mediates vascular homeostasis by producing thromboxane A2 (TXA2) through the isomerization of prostaglandin H2 (PGH2). A homology alignment of CYP5A1 with human CYPs indicates that a highly conserved I-helix threonine residue is occupied by an isoleucine at position 346 in CYP5A1. We find that...

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Identifiers

PMID: 25900452
DOI: 10.1016/j.bpc.2015.03.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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