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Article

Identification of the contact region responsible for the formation of the homomeric CYP1A2•CYP1A2 complex.

The Biochemical journal - 11 Jun 2021

Saha Aratrika, Connick J Patrick, Reed James R, Lott Charles S, Backes Wayne L

Abstract excerpt

Previous studies showed that cytochrome P450 1A2 (CYP1A2) forms a homomeric complex that influences its metabolic characteristics. Specifically, CYP1A2 activity exhibits a sigmoidal response as a function of NADPH-cytochrome P450 reductase (POR) concentration and is consistent with an inhibitory CYP1A2•CYP1A2 complex that is disrupted by increasing [POR] (Reed et al. (2012) Biochem. J. 446, 489-497). The goal of...

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PMID: 34032264
DOI: 10.1042/BCJ20210269
PMCID: PMC8522333

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