Article
Cell-Free Expression of Proton-Coupled Folate Transporter in the Presence of Nanodiscs.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022
Do Hoa Quynh, Jansen Michaela
Abstract excerpt
Proton coupled folate transporter (PCFT) is an integral membrane protein with 12 transmembrane segments localized to the plasma membrane. PCFT is the main route by which folate, vitamin B9, from dietary sources enters mammalian cells in the small intestine. Loss-of-function mutations in this membrane transport protein cause hereditary folate malabsorption, and upregulation of PCFT has been reported in cancer...
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