Article
No association of SORT1 gene polymorphism with sporadic Alzheimer's disease in the Chinese Han population.
Neuroreport - 19 Jun 2013
Zeng Fan, Deng Yong-Ping, Yi Xu, Cao Hong-Yuan, Zou Hai-Qiang, Wang Xin, Liang Chun-Rong, Wang Ye-Ran, Zhang Li-Li, Gao Chang-Yue, Xu Zhi-Qiang, Lian Yan, Wang Lin, Zhou Xin-Fu, Zhou Hua-Dong, Wang Yan-Jiang
Abstract excerpt
Increasing evidence shows that sortilin (encoded by SORT1 gene), a member of the vacuolar protein sorting 10 family of sorting receptors, can modulate amyloid-β peptides (Aβ) metabolism and clearance, as well as mediate the neurotoxicity of the Aβ oligomer and proneurotrophins, thus playing diver...
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