Article
No association of SORT1 gene polymorphism with sporadic Alzheimer's disease in the Chinese Han population.
Neuroreport - 19 Jun 2013
Zeng Fan, Deng Yong-Ping, Yi Xu, Cao Hong-Yuan, Zou Hai-Qiang, Wang Xin, Liang Chun-Rong, Wang Ye-Ran, Zhang Li-Li, Gao Chang-Yue, Xu Zhi-Qiang, Lian Yan, Wang Lin, Zhou Xin-Fu, Zhou Hua-Dong, Wang Yan-Jiang
Abstract excerpt
Increasing evidence shows that sortilin (encoded by SORT1 gene), a member of the vacuolar protein sorting 10 family of sorting receptors, can modulate amyloid-β peptides (Aβ) metabolism and clearance, as well as mediate the neurotoxicity of the Aβ oligomer and proneurotrophins, thus playing diverse roles in the pathogenesis of Alzheimer's disease. To assess the association between single nucleotide polymorphism...
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