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Article

Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation.

PLoS genetics - 1 May 2013

Atlasi Yaser, Noori Rubina, Gaspar Claudia, Franken Patrick, Sacchetti Andrea, Rafati Haleh, Mahmoudi Tokameh, Decraene Charles, Calin George A, Merrill Bradley J, Fodde Riccardo

Abstract excerpt

Canonical Wnt signaling plays a rate-limiting role in regulating self-renewal and differentiation in mouse embryonic stem cells (ESCs). We have previously shown that mutation in the Apc (adenomatous polyposis coli) tumor suppressor gene constitutively activates Wnt signaling in ESCs and inhibits their capacity to differentiate towards ecto-, meso-, and endodermal lineages. However, the underlying molecular and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23658527
DOI: 10.1371/journal.pgen.1003424
PMCID: PMC3642041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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