Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Canonical Wnt Pathway Controls mESC Self-Renewal Through Inhibition of Spontaneous Differentiation via β-Catenin/TCF/LEF Functions.

Stem cell reports - 8 Sept 2020

Aulicino Francesco, Pedone Elisa, Sottile Francesco, Lluis Frederic, Marucci Lucia, Cosma Maria Pia

Abstract excerpt

The Wnt/β-catenin signaling pathway is a key regulator of embryonic stem cell (ESC) self-renewal and differentiation. Constitutive activation of this pathway has been shown to increase mouse ESC (mESC) self-renewal and pluripotency gene expression. In this study, we generated a novel β-catenin knockout model in mESCs to delete putatively functional N-terminally truncated isoforms observed in previous knockout...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Self Renewal
Share to CRISPR-Associated Protein 9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ectoderm

Share to Endoderm

Share to Hepatocyte Nuclear Factor 1-alpha

Share to Lymphoid Enhancer-Binding Factor 1

Share to Mouse Embryonic Stem Cells

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 32822589
DOI: 10.1016/j.stemcr.2020.07.019
PMCID: PMC7486219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Canonical Wnt Pathway Controls mESC Self-Renewal Through Inhibition of Spontaneous Differentiation via β-Catenin/TCF/LEF Functions.PMID 32822589Read ↗

Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewalSemantic proximity Read ↗

Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4Semantic proximity Read ↗

Wnt/β-catenin Signaling in Embryonic Stem Cell Self-renewal and Somatic Cell ReprogrammingSemantic proximity Read ↗

Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo.Semantic proximity Read ↗

Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation.Semantic proximity Read ↗

The Pleiotropic Effects of the Canonical Wnt Pathway in Early Development and PluripotencySemantic proximity Read ↗

A Regulatory Network Involving β-Catenin, e-Cadherin, PI3k/Akt, and Slug Balances Self-Renewal and Differentiation of Human Pluripotent Stem Cells In Response to Wnt SignalingSemantic proximity Read ↗

Wnt/Catenin Signaling in Adult Stem Cell Physiology and DiseaseSemantic proximity Read ↗

Defining the Role of Wnt/β‐Catenin Signaling in the Survival, Proliferation, and Self‐Renewal of Human Embryonic Stem CellsSemantic proximity Read ↗

Regulation of Induced Pluripotent Stem (iPS) Cell Induction by Wnt/β-Catenin SignalingSemantic proximity Read ↗

The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cellsSemantic proximity Read ↗

Wnt/β-Catenin Signaling Regulates Telomerase in Stem Cells and Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.