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Article

Function of Wnt/β-catenin in counteracting Tcf3 repression through the Tcf3-β-catenin interaction.

Development (Cambridge, England) - 1 Jun 2012

Wu Chun-I, Hoffman Jackson A, Shy Brian R, Ford Erin M, Fuchs Elaine, Nguyen Hoang, Merrill Bradley J

Abstract excerpt

The canonical Wnt/β-catenin signaling pathway classically functions through the activation of target genes by Tcf/Lef-β-catenin complexes. In contrast to β-catenin-dependent functions described for Tcf1, Tcf4 and Lef1, the known embryonic functions for Tcf3 in mice, frogs and fish are consistent with β-catenin-independent repressor activity. In this study, we genetically define Tcf3-β-catenin functions in mice by...

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Identifiers

PMID: 22573616
DOI: 10.1242/dev.076067
PMCID: PMC3357906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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