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Article

Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice.

Genes & development - 15 Mar 1999

Galceran J, Fariñas I, Depew M J, Clevers H, Grosschedl R

Abstract excerpt

Members of the LEF-1/TCF family of transcription factors have been implicated in the transduction of Wnt signals. However, targeted gene inactivations of Lef1, Tcf1, or Tcf4 in the mouse do not produce phenotypes that mimic any known Wnt mutation. Here we show that null mutations in both Lef1 and Tcf1, which are expressed in an overlapping pattern in the early mouse embryo, cause a severe defect in the...

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Share to Embryo, Mammalian
Share to Hepatocyte Nuclear Factor 1-alpha
Share to Limb Deformities, Congenital

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoid Enhancer-Binding Factor 1

Share to Microscopy, Electron, Scanning

Share to Wnt Proteins

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Identifiers

PMID: 10090727
DOI: 10.1101/gad.13.6.709
PMCID: PMC316557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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