Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression.

Development (Cambridge, England) - 1 Mar 2009

Gribble Suzanna L, Kim Hyung-Seok, Bonner Jennifer, Wang Xu, Dorsky Richard I

Abstract excerpt

The Lef/Tcf factor Tcf3 is expressed throughout the developing vertebrate central nervous system (CNS), but its function and transcriptional targets are uncharacterized. Tcf3 is thought to mediate canonical Wnt signaling, which functions in CNS patterning, proliferation and neurogenesis. In this study, we examine Tcf3 function in the zebrafish spinal cord, and find that this factor does not play a general role in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Body Patterning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Stem Cells

Share to Neurogenesis

Share to Spinal Cord

Share to TCF Transcription Factors

Share to Zebrafish

Share to Zygote

Source

Open in PubMed Open full text

Identifiers

PMID: 19176587
DOI: 10.1242/dev.027995
PMCID: PMC2685945

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression.PMID 19176587Read ↗

Tcf3 function is required for the inhibition of oligodendroglial fate specification in the spinal cord of zebrafish embryos.Semantic proximity Read ↗

Two tcf3 genes cooperate to pattern the zebrafish brain.Semantic proximity Read ↗

Tcf3: a transcriptional regulator of axis induction in the early embryo.Semantic proximity Read ↗

Requirement for Foxd3 in the maintenance of neural crest progenitors.Semantic proximity Read ↗

Lef1 plays a role in patterning the mesoderm and ectoderm in Xenopus tropicalis.Semantic proximity Read ↗

Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice.Semantic proximity Read ↗

Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitroSemantic proximity Read ↗

Function of Wnt/β-catenin in counteracting Tcf3 repression through the Tcf3-β-catenin interaction.Semantic proximity Read ↗

Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation.Semantic proximity Read ↗

Xenopus Meis3 protein lies at a nexus downstream to Zic1 and Pax3 proteins, regulating multiple cell-fates during early nervous system development.Semantic proximity Read ↗

Transcriptional regulation by Pax3 and TGFbeta2 signaling: a potential gene regulatory network in neural crest development.Semantic proximity Read ↗

Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.