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Article

TAF4b and TAF4 differentially regulate mouse embryonic stem cells maintenance and proliferation.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Mar 2013

Bahat Anat, Kedmi Ranit, Gazit Kfir, Richardo-Lax Inna, Ainbinder Elena, Dikstein Rivka

Abstract excerpt

TAF4b is a cell type-specific subunit of the general transcription factor TFIID. Here, we show that TAF4b is highly expressed in embryonic stem cells (ESC) and is down-regulated upon differentiation. To examine the role of TAF4b in ESC, we applied a knockdown (KD) approach. TAF4b depletion is associated with morphological changes and reduced expression of the self-renewal marker alkaline phosphatase. In contrast,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23350932
DOI: 10.1111/gtc.12030

Genes

TAF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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