Article
Impact of WNT signaling on tissue lineage differentiation in the early mouse embryo.
Development, growth & differentiation - 1 Sept 2011
Tanaka Satomi S, Kojima Yoji, Yamaguchi Yasuka L, Nishinakamura Ryuichi, Tam Patrick P L
Abstract excerpt
WNT signaling activity is involved in the regulation of many cellular functions, including proliferation, migration, cell fate specification, maintenance of pluripotency and induction of tumorigenicity. Here we summarize recent progress towards understanding the regulation of canonical WNT/β-catenin signaling activity through feedback regulatory loops involving the ligands, agonists and antagonists, the...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Cell Differentiation
- Cell Movement
- Embryo, Mammalian
- Embryonic Development
- Embryonic Stem Cells
- Frizzled Receptors
- Gene Expression Regulation, Developmental
- Germ Layers
- Glypicans
- Heart
- Heparan Sulfate Proteoglycans