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Article

Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting

29 Oct 2009

Abstract excerpt

BACKGROUND: Testicular germ cell tumors (TGCTs) are classified as seminonas or non-seminomas of which a major subset is embryonal carcinoma (EC) that can differentiate into diverse tissues. The pluripotent nature of human ECs resembles that of embryonic stem (ES) cells. Many Wnt signalling species are regulated during differentiation of TGCT-derived EC cells. This study comprehensively investigated expression...

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Share to Sperm and Testicular Function
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PMID: 19874621
DOI: 10.1186/1471-2407-9-383

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