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Article

High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells.

Stem cell reports - 10 May 2016

Famili Farbod, Brugman Martijn H, Taskesen Erdogan, Naber Brigitta E A, Fodde Riccardo, Staal Frank J T

Abstract excerpt

Canonical Wnt signaling regulates the self-renewal of most if not all stem cell systems. In the blood system, the role of Wnt signaling has been the subject of much debate but there is consensus that high Wnt signals lead to loss of reconstituting capacity. To better understand this phenomenon, we have taken advantage of a series of hypomorphic mutant Apc alleles resulting in a broad range of Wnt dosages in...

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Source

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Identifiers

PMID: 27167156
DOI: 10.1016/j.stemcr.2016.04.009
PMCID: PMC4939829

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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